Anti-inflammatory and anti-aging activity of hydrogel with active ingredient Phyllantus emblica L. fruit nanosimplicia

Anti-inflammatory and anti-aging activity of hydrogel with active ingredient Phyllantus emblica L. fruit nanosimplicia

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Background: Phyllantus emblica contains quite high levels L-Tryptophan of vitamin C as an antioxidant, premature aging and anti-inflammatory.Simplicia is formulated into a hydrogel because it has good dispersion power on the skin.Objective: This research aims to develop a hydrogel formula with the active ingredient Phyllantus emblica L.Fruit nanosimplicia as an anti-inflammatory and anti-aging.Methods: Nano simplicia is made using a high-energy ball mill and characterized through phytochemical analysis, particle size analysis, Fourier transform infrared spectroscopy, and scanning electron microscopy.

Hydrogels are formulated with simplicia concentrations (2, 4, 6 %).Assessment of hydrogels encompasses organoleptic evaluations, consistency, dispersibility, pH, thickness, stability, skin irritation, efficacy against aging, and anti-inflammatory.Results: The anti-aging hydrogel made from P.emblica fruit nanosimplicia is a dark brown, uniform substance with a pH range of 5.26-6.

28 and spreadability between 6.1-6.8.It remains stable after 4 weeks of storage at room temperature and is non-irritating to the skin.Results showed that the 6 % hydrogel preparation was the most effective in increasing moisture by 17.

90 %, improving evenness by 15.83 %, reducing pore size by 15.30 %, diminishing pore spots by 22.67 %, and decreasing wrinkles by 28.06 %.

Hydrogel concentrations of 2 %, 4 %, and 6 % showed inhibitory results of 0.7 %, 6.6 %, Maori Design Guitar Straps and 8.19 % respectively.Conclusion: Phyllanthus emblica nanosimplicia was successfully incorporated into a hydrogel formulation and remained stable for four weeks of storage.

Hydrogel 6% exhibited superior anti-aging and anti-inflammatory properties.